Mariam Jamal-Hanjani is a Thoracic Medical Oncologist and Group leader at the University College London Cancer Institute. Her early research in chromosomal instability and intratumour heterogeneity demonstrated the prognostic relevance of genomic instability in lung cancer. In 2012 she was awarded a Cancer Research UK Clinical Research Fellowship to complete her PhD studies with Prof. Charles Swanton in lung cancer evolution for which she was awarded the McElwain and the Sylvia Lawler Scientific Prizes. In 2016 she was awarded an NIHR Clinical Lectureship to continue her work in the field of cancer evolution and in 2021 she was awarded a Cancer Research UK Career Establishment Award to study the biological processes driving death in lung cancer. She is Principal Investigator of the TRACERx lung cancer evolution study, Chief Investigator of the PEACE research autopsy programme, and Chief Scientific Investigator of the first-in-human CHIRON study investigating the clinical activity of autologous clonal neoantigen T cells in patients with advanced non-small cell lung cancer. She is a co-investigator on two Cancer Grand Challenges focussed on the study of extrachromosomal DNA and cachexia, and her lab is focussed on studying tumour evolution and immune escape in the metastatic setting, and catabolic mediators of cancer cachexia.